The impact of early norepinephrine administration on outcomes of patients with sepsis induced hypotension, randomized controlled prospective study

Background: Hypovolemia and reduced vascular tone have a role in determining the severity of hypotension septic shock. The risk fluid overload is presented as common complication during shock resuscitation. study aimed to investigate effect early norepinephrine administration on outcomes patients with sepsis induced hypotension.Methods: This was performed 64 diagnosed sepsis. were randomly allocated into two groups, Group A: Received 30ml /kg ringer's lactate solution after first presentation then added when persistent mean arterial pressure still lower than mmHg despite adequate B: combined infusion (0.05 mic/kg/min). Results: Time reach MAP ≥ 65 showed statistically significant decrease group B compared A. Mean blood Showed increase In there heart rate changes There A volume intravenous administered, quantity dose 1st day, duration norepinephrine, total leukocyte count, urea, serum creatinine 30 days mortality. Urine output at 1h, 6h, 12h 24h follow up.Conclusion: Norepinephrine part initial resuscitation result decreased time target MAP, IV requirement, lowers levels, decreases mortality rate.